IS THERE A RELATİONSHİP BETWEEN DİSEASE SEVERİTY AND UPPER AİRWAY STENOSİS LEVEL AND SYSTEMİC IMMUNE INFLAMMATORY INDEX İN OBSTRUCTİVE SLEEP APNEA SYNDROME?
1Sağlık Bilimleri Üniversitesi Konya Şehir Hastanesi, Kulak Burun Boğaz Hastalıkları, Konya, Türkiye2Sağlık Bilimleri Üniversitesi,Konya Şehir Hastanesi, Göğüs Hastalıkları, Konya, Türkiye Objective: It is known that oxidative stress and airway inflammation have an important role in the pathophysiology of obstructive sleep apnea syndrome (OSAS). In this study, we aimed to determine whether there is a relationship between systemic immune inflammatory index (SII) parameter and apnea hypopnea index (AHI) and upper airway stenosis levels in OSAS patients.
Material and Methods: The files of the patients who were diagnosed with OSAS and simple snoring by performing polysomnography test in the chest diseases outpatient clinic of our hospital and referred to the otolaryngology polyclinic for examination between September 2021 and May 2022 were retrospectively scanned. Results of polysomnography test and blood hemogram parameters and endoscopic examination findings of the patients were recorded. Patients with AHI 5 and above were included in the OSAS group, and those with AHI below 5 were included in the study as the control group.
Results: A total of 165 patients were included in our study. While there were 87 patients in the OSAS group, there were 78 patients in the control group. While the median SII value was 509,625 in the OSAS group, it was 417,644 in the control group, and there was no statistically significant difference between the two groups (p>0.05). There was no significant difference between the control and OSAS groups in terms of Neutrophil Lymphocyte ratio (NLR) and Platelet Lymphocyte ratio (PLR) (p>0.05). There was no significant relationship between the number of upper airway stenosis levels and NLR, PLR, AHI and SII (p>0.05).
Conclusion: OSAS is a disease with many components and its pathophysiology has not been fully elucidated. In our study, there was no significant difference between the OSAS and control groups in terms of SII. In addition, we did not find a significant relationship between SII and AHI and the number of upper airway stenosis. We think that prospective studies consist of homogeneous groups in terms of additional comorbid diseases that examine the relationship between OSAS and SII and are needed in this area.
Keywords : Obstruktif uyku apne sendromu, sistemik immün inflamatuar indeks, oksidatif stres