PROGNOSTIC IMPORTANCE OF HYPOXIA-INDUCIBLE FACTOR 1-ALPHA AND NUCLEAR FACTOR KAPPA B IN EARLY-STAGE GLOTTIC LARYNGEAL SQUAMOUS CELL CARCINOMA TREATED WITH RADIOTHERAPY
1Bakırköy Dr Sadi Konuk Eğitim ve Araştırma Hastanesi KBB Anabilim Dalı, KBB, İstanbul, Turkey2Eskişehir Osmangazi Üniversitesi KBB Anabilim Dalı, KBB, Eskişehir, Turkey
3Eskişehir Osmangazi Üniversitesi Radyasyon Onkolojisi Anabilim Dalı, Radyasyon Onkolojisi, Eskişehir, Turkey
4Eskişehir Osmangazi Üniversitesi Patoloji Anabilim Dalı, Patoloji, Eskişehir, Turkey Objective: Early-stage glottic laryngeal squamous cell carcinoma has good mortality and morbidity rates with radiotherapy. However, recurrent cases are at risk of increased morbidity and mortality. Therefore, the identification of new prognostic markers is needed.
Material and Methods: Forty patients with early-stage glottic carcinoma managed with radiotherapy were included in this study. Immunohistochemical evaluation was performed for Nuclear factor-kappa B and Hypoxia-inducible factor 1-alpha from biopsy specimens. The relationship between overall survival and investigated parameters was analyzed by Kaplan-Meier and regression analysis.
Results: There were 11 recurrences and 20 deaths occurred during the follow-up period. There was no significant relationship between Nuclear factor-kappa B and Hypoxia-inducible factor 1-alpha staining and overall survival. There were no significant correlations between age, smoking status, differentiation, T stage, and anterior commissure involvement with Nuclear factor-kappa B and Hypoxia-inducible factor 1-alpha staining.
Conclusion: It seems pretreatment Nuclear factor-kappa B and Hypoxia-inducible factor 1-alpha expression levels do not correlate with overall survival in early-stage glottic carcinoma primarily managed with radiotherapy.
Keywords : Glottic; cancer; radiotherapy; survival; resistance