THE EFFECTS OF WOUND HEALING AGENTS’ APPLICATION FOLLOWING NASAL AND PARANASAL SINUS SURGERY
1Süleyman Demirel Üniversitesi Tıp Fakültesi , KBB Anabilim Dalı, Isparta, Türkiye2Süleyman Demirel Üniversitesi Tıp Fakültesi , Patoloji Anabilim Dalı, Isparta, Türkiye Background: Nasal packing materials, used after nasal surgery or for cessation of epistaxis, are impregnated with some moisteners and lubricators such as paraffin or antibiotic ointments. The purpose of this study was to determine whether wound healing agents can be used in the impregnation of nasal packing materials.
Materials and Methods: Forty eight Pasteurella-free New Zeeland white male rabbits were used for this study. After the incision of mucosae of nasal septum and lateral nasal walls of both nasal cavities, soft paraffin, clostridiopeptidase-A, nitrofurazone and asiaticoside ointments were administered into both nasal cavities. The effects of wound healing agents during early and late phases of wound healing were evaluated histopathologically.
Results: Asiaticoside and clostridiopeptidase-A have more preventive effects, regarding early mucosal edema, than nitrofurazone and control groups (p<0.05). Asiaticoside and clostridiopeptidase-A have more preventive effects, regarding late ciliary loss, than nitrofurazone and control groups (p<0.05).
Conclusions: Wound healing agent “asiaticoside” has more beneficial effects on nasal packing and nasal surgery than clostridiopeptidase-A and nitrofurazone which have nearly the similar effects.
Keywords : Wound healing, nasal surgery, asiaticoside, clostridiopeptidase-A