KBB-Forum 2010 , Cilt 9, Sayı 3


Dr. Selim Sermed ERBEK, Dr. ÖzgüL TOPAL, Dr. Bilge ÇELİK, Dr. Seyra ERBEK
Başkent Üniversitesi Tıp Fakültesi, KBB Anabilim Dalı, Ankara, Türkiye Objective: Etiopathogenesis of nasal polyposis is still under debate. It is frequently associated with asthma and aspirin intolerance. The aim of this study was to evaluate the clinical characteristics of nasal polyp patients with aspirin intolerance.

Materials and Methods: Medical records of 163 cases with nasal polyposis was inspected retrospectively. Impact of aspirin sensitivity on the severity of the disease was evaluated.

Results: Twenty-three (14.1%) of the patients with nasal polyposis had also aspirin intolerance. Sixty-nine point five percent (69,5%) of the cases with aspirin intolerance and 30,9% of patients without aspirin intolerance were female (p=0,001). There was no association of aspirin intolerance with the age of disease onset (p=0,111). Polyps were obliterating the nasal cavity in 60,8% of patients with aspirin intolerance while in 22,3% of the patients without aspirin intolerance (grade 3 nasal polyposis). The difference was statistically significant (p<0,001). According to the computerized tomography findings, the mean of Lund-Mackay score was 22,2±2,7 in patients with aspirin intolerance while it was 15,32±5,8 in patients without aspirin intolerance (p<0,001). The need for surgery in recurrent cases was also significantly high in cases with aspirin intolerance (p=0,006).

Conclusion: In cases of nasal polyposis with aspirin intolerance, the severity of the disease is more prominent. Consequently, these patients' treatment and follow-up are of special importance. Keywords : Nasal polyposis, aspirin, asthma, severity of disease