IS THERE ANY PROGNOSTIC INFLUENCE OF TUMOR-ASSOCIATED TISSUE EOSINOPHILIA IN LIP CANCER?
1Numune Training and Research Hospital. Otorhinolaryngology and Head and Neck Surgery Department, Adana, TURKEY2Numune Training and Research Hospital, Pathology Department, Adana, TURKEY
3Aşkım Tüfekçi Hospital. Otorhinolaryngology and Head and Neck Surgery Department, Adana, TURKEY Purpose: Many prognostic factors have been identified for squamous cell carcinoma (SCC) occurring in the oral cavity, one of which is tumor-associated tissue eosinophilia (TATE). The aim of this study was to investigate the effects of TATE on prognosis and its relationship with clinical and pathological variables only in lip cancers in order to create a homogenous study group.
Materials and Methods: This retrospective study included 31 consecutive patients with a diagnosis of lip cancer who were admitted to Health and Science University Adana City Hospital, Ear-Nose-Throat Clinic from September 2010 to September 2016 and treated with surgery.
Results: When the relationship of TATE with other variables was investigated, a significant relationship was found only with smoking. Smokers had higher mild intratumoral TATE. There was no significant relationship of tumor grade, recurrence, neck dissection, blood eosinophilia, perineural invasion, lymph node metastasis, differentiation level, and invasion depth with peritumoral-intratumoral TATE. No statistically significant relationship between peritumoral TATE and smoking was found.
Conclusion: The predictors of recurrence or prognosis at the time of initial diagnosis are inadequate in lip cancer. It is promising to evaluate eosinophilia as a possible diagnostic tool, which can already be assessed on hematoxylin and eosin (H&E)-stained tumor slides. For this reason, it may be better to include findings on eosinophilia in the pathology report.
Keywords : Lip cancer, squamous cell carcinoma, TATE, eosinophilia, smoking