KBB-Forum 2012 , Cilt 11, Sayı 3

HISTOPATHOLOGIC EVALUATION OF THE EFFECTS OF SYSTEMIC METHYL-PREDNISOLONE TREATMENT ON EOSINOPHILIC NASAL POLYPOSIS

Kazım BOZDEMİR, MD; Behcet TARLAK,MD; Hasan ÇAKAR,MD; Ahmet DOBLAN, MD; Ahmet KUTLUHAN, MD
Ankara Atatürk Eğitim ve Araştırma Hastanesi, KBB-BBC, Ankara, Türkiye Aim: To study the histopathologic effects of systemic cortisone treatment on eosinophilic nasal polyposis.

Material and method: Systemic corticosteroid treatments were used in 25 patients with nasal polyposis. An oral dose of 1mg/kg prednisolone was given for the first 5 days, than the steroid was tapered in 17 days by decreasing it's dose 5mg per day Nasal mucosal biopsies taken before and after the treatment were evaluated histopathologically.

Results: Following medical treatment, a significant reduction in edema and eosinophilia, and an increase in neutrophilia were detected (p<0.05). Other histopathological parameters showed no significant change (p>0.05).

Conclusion: Corticosteroid treatments have limited therapeutic effect by histopathologic level on nasal polyposis. Keywords : Nasal polyposis, corticosteroids, histopathology