EFFECT OF PROPOLIS ON NASAL MUCOSA OF RADIOTHERAPHY APPLIED RATS
1Sancaktepe Sehit Prof.Dr.Ilhan Varank Training and Research Hospital, Otorhinolaryngology and Head & Neck Surgery Department, İstanbul, Turkey2Gaziosmanpasa University Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, Tokat, Turkey
3Sakarya University Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, Sakarya, Turkey Objective: The aim of this study is to examine the effect of propolis on radiotherapy (RT) applied rat nasal mucosa.
Material and Method: Seven of the rats constituted the control group while 30 were divided into three experimental groups, each with 10 rats. A single dose RT of 15 Gray (Gy) was applied to the head and neck area of the rats in G1, G2 and G3 groups. Following RT, water-soluble propolis was given intraperitoneally every day for two weeks as 100 mg/kg to G2 group and as 200 mg/kg to G3 group.
Results: Histological analyses showed that inflammation score was lowest in the control group and highest in G1 group which received RT only. In the G3 group, the inflammation score decreased to a level similar to that of the control and was statistically different from those of the G1 and G2 groups (p < 0.05). Olfactory epithelial thickness was significantly less in G1 group than in control and G3 groups (p < 0.05). Submucosa thickness of the concha region was significantly different in G1 group (p < 0.05) compared to all other groups, and G2, G3 and control groups had decreasing submucosa thickness values.
Conclusion: Our study is the first to examine the effect of propolis on the nasal mucosa of radiation-exposed rats. Systemic propolis administration was shown to reduce inflammation and to enhance healing of nasal mucosa in radiation-exposed rats in a dose dependent manner.
Keywords : Nasal mucosa; propolis; radiotherapy; rat