KBB-Forum 2023 , Cilt 22, Sayı 1

COPEPTIN AND CAROTID INTIMA-MEDIA THICKNESS AS PREDICTOR BIOMARKERS OF EARLY CARDIOVASCULAR DISEASE IN SEVERE NASAL SEPTUM DEVIATED PATIENTS

Harun SOYALIÇ 1, MD; Yeliz DADALI 2, MD; Bilal İLANBEY 3, MD; Mustafa ÇELIK 4, MD; Muhammed ALPASLAN 2, MD; Evrim ÜNSAL TUNA 5, MD;
1Ahi Evran Üniversitesi Tıp Fakültesi, Kulak Burun Boğaz, Kırşehir, Turkey
2Ahi Evran Üniversitesi Tıp Fakültesi, Radyoloji, Kırşehir, Turkey
3Ahi Evran Üniversitesi Tıp Fakültesi, Biyokimya, Kırşehir, Turkey
4Ahi Evran Üniversitesi Tıp Fakültesi, Kardiyoloji, Kırşehir, Turkey
5Sağlık Bilimleri Üniversitesi Bilkent Şehir Hastanesi, Kulak Burun Boğaz, Ankara, Turkey Objective: In our study, we aimed to analyse the carotid intima-media thickness (CIMT), systemic cardiac failure parameters, and serum copeptin concentrations in patients with severe nasal septum deviation (NSD) causing severe nasal obstruction and evaluating the diagnostic value of these parameters for the early onset of cardiovascular diseases in these patients.

Methods: The sample involved 57 patients with severe NSD and 50 individuals in the control group. The diagnosis of severe NSD was made following nasal endoscopic examination. CIMT and cardiac failure parameters were evaluated with carotid ultrasonography and echocardiography. Copeptin levels in the sera of the patients were examined with the enzyme-linked immunosorbent assay method (ELISA).

Results: Right and left CIMT values, serum copeptin measurements, and log (serum copeptin level) values were significantly higher in the patient group in comparison to the control group (p<0.001 for all). In the results of the univariate analysis, the log serum copeptin and right and left carotid intima thickness variables were significantly associated with severe NSD (p<0.001). The multivariate analysis results demonstrated a significant relationship of only log serum copeptin with NSD (p=0.015). The ROC (receiver operating characteristic) curve examinations of the log serum copeptin values of the patients with severe NSD revealed an AUC (area under the curve) value of 0.72. The specificity of this measure was 86%, and its sensitivity was 50.9%.

Conclusion: When used together, serum copeptin values and CIMT measurements can serve as biomarkers for the early monitoring of cardiovascular diseases in patients with severe NSD causing complete nasal congestion. Keywords : Carotid intima-media thickness, cardiovascular disease, copeptin, hypoxia, nasal septum deviation