KBB-Forum 2022 , Cilt 21, Sayı 1

THE ROLE OF LYMPHOCYTE-MONOCYTE RATIO IN DETERMINING PREDICTING RECURRENCE AND PROGNOSIS IN LARYNGEAL CANCER

Senem Kurt DİZDAR 1, MD; Meltem AKPINAR 1, MD; Nazlı EKŞİ 2, MD; Didem RIFKI 3, MD; Denizhan DİZDAR 4, MD; Şermin Tülay BAŞAK 5, MD; Berna Uslu COŞKUN 1, MD;
1SBÜ Şişli Hamidiye Etfal SUAM, KBB Anabilim Dalı, İstanbul, Turkey
2Manavgat State Hospital, KBB Kliniği, Antalya, Turkey
3Doğu Akdeniz Üniversitesi Tıp Fakültesi, KBB Kliniği, Lefkoşa, Kuzey Kıbrıs TC
4Özel Muayenehane, KBB Kliniği, İstanbul, Turkey
5SBÜ Şişli Hamidiye Etfal SUAM, Patoloji Anabilim Dalı, İstanbul, Turkey Objective: Although inflammation plays a role in tumour rejection, it may also contribute to the progression of oncogenesis. Our goal was to investigate the lymphocyte-to-monocyte ratio (LMR) and its effects on cancer prognosis in laryngeal cancer patients.

Methods: Patients treated in our clinic between 2003 and 2014 for a diagnosis of laryngeal squamous cell cancer were analysed retrospectively. A total of 164 patients were included in the study. Patients were divided into groups according to perivascular invasion status [PVI(+) and PVI(-)], thyroid cartilage invasion status [TCI(+) and TCI(-)], metastatic lymph node [LAP(+) and LAP(-)], perineural invasion status [PNI(+) and PNI(-)] and tumour stage (T1-T4). Differences of pretreatment LMR among the groups were evaluated. The relationships of LMR with survival time and recurrence were evaluated.

Results: There was a statistically significant inverse correlation between T stage (T1-T4a), and LMR level (p=0.001). LMR was significantly lower in the TCI(+) (p=0.004), LAP(+) (p=0.004), and PVI(+) (p=0.006) groups. The mean LMR in the recurrence (+) group was lower than in the recurrence (-) group for all stages, but a statistically significant difference was detected only in patients with early stage cancer (T1 and T2) (p=0.024 and 0.052, respectively). An increased recurrence rate was found in patients with an LMR≤3.01 (sensitivity:61.1%, specificity:60.9%). Among all of the prognostic factors, a low LMR was found to be the most important independent factor determining cancer-related death.

Conclusions: A decreased LMR, particularly in the early stages of laryngeal cancer, is associated with high recurrence rates and a poor prognosis. Keywords : Lymhocyte Monocyte Ratio; Laryngeal Cancer; Prognosis; Recurrence