KBB-Forum 2017 , Cilt 16, Sayı 1

WHITE BLOOD CELL COUNT TO MEAN PLATELET VOLUME RATIO: A NOVEL MARKER FOR OBSTRUCTIVE SLEEP APNEA

Rauf Oğuzhan KUM1, MD; Fatma Cemre SAZAK KUNDİ1, MD; Müge ÖZCAN2, MD; Yavuz Fuat YILMAZ1, MD; Nurcan YURTSEVER KUM1, MD; Adnan ÜNAL1, MD
1Ankara Numune Eğitim ve Araştırma Hastanesi, Kulak Burun Boğaz Hastalıkları, Ankara, Turkey
2Ankara Numune Eğitim ve Araştırma Hastanesi ve Hitit Üniversitesi, Kulak Burun Boğaz Hastalıkları, Ankara, Turkey Objective: The aim of this study was to investigate the association between white blood cell count to mean platelet volume (MPV) ratio (WMR) and other complete blood count (CBC) parameters with obstructive sleep apnea syndrome (OSAS).

Materials and Methods: This cross-sectional historical cohort study was performed on 244 patients who were diagnosed as OSAS and a control group consisted of 80 individuals with simple snoring. Patients with OSAS were also divided into 3 groups according to severity of the disease. The groups were compared for WMR and the other CBC parameters, and the correlations between WMR and polysomnography (PSG) findings were investigated as well.

Results: The mean WMR and mean neutrophil to lymphocyte ratio (NLR) were significantly higher in patient groups compared with the control group (p = 0.001, p = 0.001, respectively). There was statistically significant difference between the patients groups, when the WMR values were compared (p = 0.001). The mean WMR of mild OSAS group was significantly lower compared to the moderate and severe OSAS groups (p = 0.004 and p = 0.001, respectively). There was a significant positive correlation between WMR and AHI, as well as between WMR and severity of OSAS in patient group (p = 0.001 and p = 0.001, respectively). The WMR had the highest area under ROC curve thus it thought to be more capable of discriminating the diagnosis of OSAS than the other CBC parameters. We found that WMR showed better correlation with OSAS, compared to the other CBC parameters.

Conclusion: WMR might be used as a new and important marker in OSAS since it was found high in patients with OSAS and significantly correlated with AHI and severity of the disease. Keywords : Complete blood count, inflammation, neutrophil to lymphocyte ratio, obstructive sleep apnea syndrome, white blood cell count to mean platelet volume ratio