INVESTIGATION OF THE EFFECT OF STRONTIUM ON THE RECOVERY OF EXPERIMENTAL SUBCONDYLAR MANDIBULAR FRACTURES BY USING A SPONGOSTAN AS A CARRIER
1Cumhuriyet üniversitesi, KBB, Sivas, Turkey2Cumhuriyet üniversitesi, Eczacilik, Sivas, Turkey
3Cumhuriyet üniversitesi, Patoloji, Sivas, Turkey
4Cumhuriyet üniversitesi, Dermatoloji, Sivas, Turkey Background: We aimed to investigate whether or not we achieved a bone recovery similar to or better than positive results we obtained in single dose local administration of strontium into fracture line we made previously by using spongostan as strontium carrier.
Material and Methods: The study was conducted with 24 male Wistar-albino rats. They were randomly divided into three groups: group SC3 [receiving 3% SC-soaked spongostan ( n=8), group SC5 [receiving 5% SC-soaked spongostan (n=8); and group C [only spongostan (n=8)]. A full thickness surgical osteotomy was performed in the subcondylar area. A 0.5x0.5 cm spongostan soaked with 3% SC in group SC3 and 5% SC in group SC5 was placed in the fracture area and in group C, only spongostan was placed in fracture line.
Postoperative 21 day, the animals mandible was dissected and fractured hemimandibles were obtained for histopathological examination. The amount of the ossification was scored out of 10 for each section.
Results: There was significantly immature bone and small amount of cartilage in the group SC3, completely immature bone in the group SC5 and the group C. When the groups were compared in terms of bone healing scores, there was no statistical difference between the groups (p>0.05).
Conclusions: Because the efficiency of using strontium alone was revealed in our first study, we are of the opinion that it is required to conduct future studies in which repeating local strontium injections are tried or different carrier systems are used in order to increase the positive effect of strontium on bone recovery.
Keywords : Strontium Chloride, subcondylar mandibular fractures, fracture healing, spongostan