INTERFERENCE BETWEEN HELICOBACTER PYLORI AND SQUAMOUS CELL CARCINOMA OF THE LARYNX: HISTOPATHOLOGIC AND SEROLOGIC STUDY

¹Ankara Numune Eğitim ve Araştırma Hastanesi, KBB, Ankara, Türkiye
²Ankara Yüksek İhtisas Hastanesi, Patoloji, Ankara, Türkiye
³Ankara Hastanesi, Mikrobiyoloji, Ankara, Türkiye The presence of IgG antibodies against H. pylori antigens in the sera of 30 patients who are diagnosed with squamous cell carcinoma of the larynx were tested using ELISA technique. The presence of H. pylori in the larynx specimens was also investigated microscopically. At least two fresh histopathologic samples were taken each from tumoral and non-tumoral tissues. Biopsies were stained with haematoxylin and eosin, and giemsa. The incidence of seropositivity was found to be 60%. H. pylori was detected in 12 (40%) patients' histopathologic examinations. In 6(%20) patients, bacteria were found in both normal and tumoral tissues, and in 6 patients were found in only tumor tissue. H. pylori was detected in specimens of 50% of the seropositive patients. Although we detected H. pylori in laryngeal specimens, we could not explain its role on carcinogenesis. Further studies to determine the role of HP as a carcinogen and its relationship with other environmental factors in laryngeal cancer are warranted. Keywords : Larynx, squamous cell carcinoma, helicobacter pylori