KBB-Forum 2013 , Cilt 12, Sayı 3

THE EFFECTS ON TREATMENT OUTCOMES OF CLINICAL AND PATHOLOGICAL FACTORS, IN HEAD AND NECK ADENOID CYSTIC CARCINOMA THAT RECEIVED RADIOTHERAPY

Dr. Ö. Petek ERPOLAT, Dr. Hüseyin BORA, Dr. Ömer YAZICI, Dr. Müge AKMANSU
Gazi Üniversitesi Tıp Fakültesi, Radyasyon Onkolojisi, Ankara, Türkiye Objective: The purpose of the study is to evaluate the local control and survival outcomes and to investigate the clinical and pathological factors on treatment results of patients who received postoperative radiotherapy.

Methods: The retrospective analysis of 23 patients treated in our department was investigated. The tumor site of 7 patients were major salivary glands and the tumor site of 16 patients were minor salivary glands. The patient numbers of T1, T2, T3, T4 tumor stage were 0 (%0), 6 (%26), 5 (%22) and 12 (%52), respectively. Lymph node involvement of 19 (%82,5) patients were negative and for 4 (%17,5) patients were positive. The perinodal invasion, bone invasion and positive surgical margin were %39, %52 and %61 of patients, respectively. Surgery and postoperative radiotherapy were applied to all patients. The mean radiotherapy dose was 64 Gy (46-70). The concomitant chemoradiotherapy was applied to 6 (%17,5) of patients. The local-regional control, disease-free survival and overall-survival were analyzed after completion of combined therapy.

Results: After median 46 months follow-up time; 5 and 10 years local control, disease-free survival and overall-survival rates were 88% and 77%; 65.5% and 50%; 74.5% and 53%, respectively. The tumor stage of T4 , lymph node metastasis, bone invasion and positive surgical margin were found as prognostic factors that effect negatively. The distant metastasis rate was 30.5%.

Conclusion: As a result of this study, the negative prognostic factors in patients with adenoid cystic carcinoma of head and neck region was compatible with literature. Higher distant metastasis rate was reducing the chance of cure in these patients. The new agents are needed to control systemic disease. Keywords : Adenoid cystic carcinoma, head-neck, surgery, radiotherapy