KBB-Forum 2005 , Cilt 4, Sayı 3

THE EFFECTS OF DIFFERENT AGENTS ON THE DEVELOPMENT OF MYRINGOSCLEROSIS AND HEALING OF TYMPANIC MEMBRANE PERFORATION

Dr. Bülent Ferdi ÖZEL1, Dr. Hasan YASAN1, Dr. Metin ÇİRİŞ2, Dr. Harun DOĞRU1, Dr. Özden ÇANDIR2
1Süleyman Demirel Üniversitesi Tıp Fakültesi, KBB Anabilim Dalı, Isparta, Türkiye
2Süleyman Demirel Üniversitesi Tıp Fakültesi, Patoloji Anabilim Dalı, Isparta, Türkiye Background: The effects of some antioxidant and anti-inflammatory agents on the development of myringosclerosis had been investigated in some previous studies. The aim of this study was to evalute the effects of wound healing agent dexpanthenol, oxidant agent H2O2 and antioxidant agent erdostein on the healing of tympanic membrane perforation and development of myringosclerosis.

Materials and Methods: Twenty Sprague – Dawley rats were bilaterally myringotomized and divided into five groups. Group 1 received no agent, groups 2, 3, 4, and 5 were applied isotonic saline (0,9%), dexpanthenol, erdostein, H2O2 (1%) in gelfoam, respectively. All tympanic membranes were examined otomicroscopically with respect to the healing of perforation. Then, tympanic membranes were harvested and evaluated by light microscopy on day 14th.

Results: The durations of closure of tympanic membrane perforation were shorter in groups of dexpanthenol and erdostein then others (p‹.05). It was longer in H2O2 group then others (p‹.05). Myringosclerosis was lesser observed in dexpanthenol and erdostein groups then others (p‹.05).

Conclusions: While erdosteine and dexpanthenol have positive effect on tympanic membrane healing, H2O2 has negative effect. Erdostein and dexpanthenol have preventive effect regarding to development of myringosclerosis. This effect is also by means of a mechanism not by means of solely antioxidant effect. Keywords : Anti-oxidant, dexpanthenol, myringosclerosis, myringotomy, rat, tympanic membrane.