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EFFECT OF ACITRETIN ON HEARING CAPACITY IN RATS

Mahmut DEMİRTAŞ 1, MD Münevver GÜVEN 2, MD Gülin Gökçen KESİCİ 3, MD Buket DEMİRCİ 4, MD
1Aydın Adnan Menderes Üniversitesi Tıp Fakültesi, Kulak Burun Boğaz Anabilim Dalı, Aydın, Türkiye
2Aydın Adnan Menderes Üniversitesi Tıp Fakültesi, Dermatoloji Anabilim Dalı, Aydın, Türkiye
3Ankara Medipol Üniversitesi Tıp Fakültesi, Kulak Burun Boğaz Anabilim Dalı, Ankara, Türkiye
4Aydın Adnan Menderes Üniversitesi Tıp Fakültesi, Tıbbi Farmakoloji Anabilim Dalı, Aydın, Türkiye Introduction: Acitretin is a widely used drug for various skin diseases, despite its high risk of toxicity. Although the effect of isotretinoin (a first generation retinoid) on hearing has been investigated, there is limited research on the effects of acitretin, a second generation retinoid, on hearing. The available data consist of case reports. Therefore, we aimed to investigate the relationship between acitretin treatment and hearing loss using distortion product otoacoustic emission (DPOAE) testing.

Methods: Twenty-seven rats (nine rats in each group) were included in the study. The rats were divided into three groups as control, acitretin 1mg/kg and acitretin 5mg/kg. DPOAE was obtained in all groups and signal-to-noise ratio (SNR) values were evaluated at the 4th and 8th weeks of the study.

Results: There was no statistically significant difference between the measurements of DPOAE SNR values in all groups. Acitretin treatment did not affect the SNR values in DPOAE measurements between control and acitretin groups and between acitretin 1mg/kg and acitretin 5mg/kg dose groups.

Conclusion: Acitretin has no adverse effect on the inner ear and is not considered ototoxic. This indicated that it can be used safely, especially in multidrug users and in various other clinical conditions. Keywords : Acitretin; Distortion Product Otoacoustic Emissions; Signal-to-Noise Ratio; Ototoxicity; Rational Drug Therapy