KBB-Forum 2021 , Cilt 20, Sayı 2

EVALUATION OF THE EFFECT OF NARINGENIN ON CISPLATIN INDUCED OTOTOXICITY IN ANIMAL MODEL

Dr. Ozan GÖKLER1
1Koç Üniversitesi, KBB BBC Anabilim Dalı, İstanbul, Türkiye Introduction: The aim of this study is to investigate the protective effect of naringenin against cisplatin induced ototoxicity by evaluating audiological and biochemical parameters.

Materials and methods: Thirty-two male rats were divided into 4 groups (control, cisplatin, naringenin + cisplatin and naringenin) including eight rats each. Distortion product otoacoustic emission (DPOAE) and auditory brainstem response (ABR) tests from both ears were performed in all groups at the beginning of the study and also on day 6. Intracardiac blood samples were taken on day 6 for assessment of biochemical parameters.

Results: In audiological assessment, in group 2 (cisplatin), there were significant decreases in DPOAE values and significant increases in ABR thresholds on day 6 as compared with other groups. In Groups 1 (control), 3 (naringenin + cisplatin) and 4 (naringenin) there was no significant difference between the pre- and posttreatment DPOAE and ABR results. In biochemichal analyses, the total oxidant status (TOS) value was significantly higher in group 2 (cisplatin) than in the other groups. The total antioxidant status (TAS) value was significantly higher in group 3 (naringenin+cisplatin) than in group 2.

Conclusions: The audiologic tests and biochemical revealed that naringenin may have protective effect against cisplatin ototoxicity by increase antioxidant levels and reduce oxidative stress parameters. Keywords : Ototoxicity, naringenin, cisplatin, otoacoustic emission, auditory brainstem response